Medical Services to Support, Restore, and Enhance
The Vigor Shot™
An investigational Hyper PRP™ program to help restore sexual performance
Supporting firmer, more durable erections
Autologous (derived from patient’s own blood). Standards-based preparation. Clinician-directed care. Some uses are investigational. Results are NOT guaranteed. Individual results and patient experiences may vary significantly.
What is the Vigor Shot™?
The Vigor Shot is minimally invasive, medical procedure that uses autologous Hyper PRP™ to support male sexual performance. Autologous means the preparation comes from your own blood. Hyper PRP is prepared via Calibrated Centrifugation™ within our standards based Growth Factor Therapy™ framework to help restore erectile function as part of a personalized plan.
Care is evaluated and delivered by a Hyper PRP provider who should be a licensed clinician. Patients are encouraged to verify provider’s credentials.
The Vigor Shot is an investigational use of Hyper PRP. Results are NOT guaranteed and vary.
Quick Transparency
READ THIS FIRST
Leading sexual medicine groups currently view penile platelet rich plasma (PRP) as experimental or investigational for erectile dysfunction. They recommend shared decision making and a discussion of established options, such as prescription medications (for example, PDE5 inhibitors), alongside any investigational choice. [13–14]
Regulatory Note for the United States
READ THIS FIRST
Devices exist that are FDA cleared to prepare PRP at the point of care. That is different from being approved for injecting PRP for erectile dysfunction, which is not FDA approved. Many 510(k) summaries state that the PRP “has not been evaluated for any clinical indications,” and device labeling commonly notes that it is not indicated for intravascular delivery. You can also report serious problems to FDA MedWatch. [19,20]
Who the Vigor Shot May Help
AT A GLANCE
Adults who want a minimally invasive option for erectile dysfunction and understand that using the Vigor Shot to support erectile function is investigational. Many people choose to incorporate PRP into a broader plan that can include lifestyle steps, established medications, and when helpful, counseling. Decisions are made with a licensed clinician using shared decision making. [13–14]
Evidence snapshot and transparency
Hyper PRP for Sexual Performance Restoration
What the research says: Small randomized trials and recent meta‑analyses have tested PRP injections for erectile dysfunction. Results are mixed. Some studies report modest short-term score improvements in erectile function for some men. Others show no clear difference compared with placebo (e.g. a saltwater injection). Most studies are small and follow people for only weeks to a few months. [1–5]
What the professionals recommend: Professional groups in sexual medicine currently advise treating penile PRP as investigational and using it mainly in research settings or with full transparency about uncertainties. [13–14]
Safety: Serious complications appear uncommon in published trials. Typical short‑term effects include soreness or bruising at the injection sites. Long‑term safety and durability are not well defined. [4–5]
What this means for you: the Vigor Shot may help some people, but benefit is not guaranteed. It should be considered an optional, investigational add‑on within a broader plan that can include well established options (for example, testosterone deficiency correction, lifestyle measures, and prescription medications). Ask your Vigor Shot provider about tracking results with validated questionnaires to help you and your clinician decide whether this Hyper PRP service is helping you. [13–14]
Key unknowns (why we’re cautious): Key unknowns include the best PRP formulation and dose, whether adding leukocytes helps or hurts, and how many sessions fit best. We do not yet know who is most likely to benefit, or how long any improvement might last. Studies use different methods, which makes comparisons hard. Larger, longer studies are needed. [1–2,8–10]
Bottom line: PRP for erectile dysfunction is promising but unproven. The Vigor Shot is an investigational option. Your provider should discuss alternatives and track your results carefully. [1–2,13–14]
How the Vigor Shot works
Investigational biomechanics & physiology
The idea: Many men want a non-surgical solution for firmer, longer lasting erections, and some are frustrated by medications that work inconsistently. The Vigor Shot uses your own blood to create a concentrated platelet product called Hyper PRP. Platelets carry natural growth factors and signaling proteins that can support the body’s repair systems. These signals may help rejuvenate blood vessels, nerves, and smooth muscle to a more youthful state. That, in turn, has the potential to restore healthier erectile function for some men. Results vary from person to person. [7–8]
How an erection works:
Erections rely on strong blood inflow, smooth muscle relaxation through nitric oxide and cyclic GMP, healthy nerve signaling, and a venous seal that helps maintain firmness. [6]
Strong blood inflow. A dependable erection begins with healthy arterial inflow through the penile arteries.
Smooth muscle relaxation. Inside the erectile chambers, nitric oxide pathways raise cGMP, which relaxes smooth muscle so the spongy spaces can fill with blood.
Healthy nerve signaling. Cavernous nerves along the erectile chambers (the spongy cylinders that fill with blood to create an erection) and around the crura (the two roots at the base of the penis) release nitric oxide that relaxes smooth muscle and starts inflow, while the dorsal nerve carries sensation that supports arousal and steadies the response.
A good seal. As the penis expands, the tunica albuginea compresses small draining veins and creates a veno occlusive seal that helps maintain firmness.
Why problems arise. If the vessel lining is unhealthy, if smooth muscle is lost or replaced with scar like tissue, or if nerve signaling drops, erections can weaken.
What Hyper PRP is and why it might help
Your own platelet concentrate. Hyper PRP is a concentrated preparation of your own platelets made from your blood. Platelets carry alpha granules that release growth factors and signaling proteins such as VEGF, PDGF, IGF-1, and TGF beta. These signals may support vessel rejuvenation, improvements in nitric oxide pathways, new vessel growth, healthier nerve signaling, and remodeling of the tissue framework—factors that contribute to firmer, stronger erections. [7–9]
Support for tiny blood vessels. In laboratory and animal studies these signals have been linked to healthier endothelial function and nitric oxide pathways that may improve how blood flows into erectile tissue. [12]
Growth of new microvessels (angiogenesis). Platelet signals such as VEGF and PDGF have been shown in preclinical models to guide the formation of tiny capillaries and improve microvascular density. In erectile tissue this could support better inflow and responsiveness, though confirmation in humans is still underway. [7,12]
Smooth muscle preservation. Preclinical work suggests a more favorable balance between smooth muscle and collagen, a change that may help achieve stronger, more reliable erections. [12]
A more supportive nerve environment. Studies in nerve injury models associate PRP with signals that support nerve fibers and erectile responses. [11–12]
Where this fits in people.These biologic goals are encouraging, yet consistent translation to people is still being studied, and results vary from person to person. [1–5,13–14]
Geek out on this
For the science curious
For the science curious
The one-minute physics of an erection. Parasympathetic signals increase nitric oxide and raise cGMP. Smooth muscle relaxes and blood fills the sinusoids. As the erectile bodies expand, the tunica albuginea compresses small draining veins and helps maintain rigidity. Problems can begin with less nitric oxide, loss of smooth muscle with more collagen, or reduced neuronal nitric oxide synthase activity. [6,11]
What lives inside platelet concentrates. Platelet alpha granules store growth factors tied to angiogenesis and repair. Release depends on dose, activation method, and the local tissue environment. If leukocytes are present they contribute both pro inflammatory and anti inflammatory signals. The overall effect depends on composition and dose. [9–10]
What preclinical ED models show. Cavernous nerve injury models report higher erectile responses and support for nitric oxide pathway markers after PRP compared with controls. Metabolic vasculopathy models such as diabetes show higher endothelial markers, more eNOS, better smooth muscle integrity, and improved intracavernosal pressure in animals. [12]
Human bridge. Randomized trials and reviews in men show mixed yet sometimes positive functional outcomes. The optimal dose, timing, and preparation for ED are not yet defined, and durable tissue remodeling in people has not been demonstrated. [1–5]
What we are still learning and how we measure it. Open questions include the ideal platelet dose, leukocyte profile, activation method, and visit schedule. We also need human data that confirm shifts in tissue markers such as microvessel density, smooth muscle to collagen ratio, and nNOS or eNOS. Another key question is which patient profiles respond best, for example men with diabetes, neurogenic causes, or venous leak patterns.
Bottom line: Mechanistic signals in animals align with what matters for firmness and staying power (inflow, sensitivity, tissue flexibility). In men, clinical outcomes vary and tissue-level proof is limited, so we treat PRP as investigational and advise providers and patients to measure results with standardized questionnaires. [1–5,11–14]
What to expect
Focused baseline evaluation. Before moving forward, you and your clinician complete a short, targeted review to confirm that the Vigor Shot is a good match for your goals and health status. It isn’t a full physical; it’s a focused review that looks at: your erectile symptoms and timeline; heart and blood vessel risks; current medications—especially blood thinners and antiplatelets; any history of easy bruising or bleeding; infection risks; and wellness factors like sleep, exercise, alcohol use, and nicotine exposure.Hormone health is considered as well. If testing points to testosterone deficiency and there are no reasons to avoid treatment, testosterone replacement options (including pellets) may be discussed in line with clinical guideliness. Because sexual wellbeing is both physical and psychological, the visit may also screen for contributors such as anxiety or relationship stress; when helpful, sex therapy can be offered alongside medical care. Together you’ll set clear, realistic goals and agree on how to track progress using validated tools like the International Index of Erectile Function—Erectile Function domain (IIEF EF) and the Erection Hardness Score. [14,6]
Sexual function history. If you’re comfortable, plan on a candid conversation about how sex is going for you right now. Topics can include erection firmness and staying power, how easily erections start, whether morning or nighttime erections are present, overall satisfaction or distress, partner context, and any discomfort or curvature. Your clinician may ask gentle screening questions about things like performance worries, avoidance, communication or relationship strain, past negative experiences, mood symptoms, or substance use. If these factors are part of the picture, adding sex therapy as a parallel track can support the medical plan so both mind and body are addressed together.
Procedure length and comfort. The Vigor Shot procedure takes about one hour to complete. Expect a standard blood draw (to collect 4 to 6 tubes of your blood), topical numbing and/or local anesthesia, about 30-45 minutes of waiting while the Hyper PRP is prepared and the topical anesthesia takes effect, a quick 5-10 minute procedure during which the PRP is precisely injected with a relatively tiny needle into multiple sites along the length of the penis, and brief post-procedure observation. Temporary pressure, soreness, or bruising are common and usually resolve on their own. [4–5]
Program structure. Our Hyper PRP Sexual Performance Restoration protocols recommend two Vigor Shots spaced about 1 to 3 months apart, with follow‑ups at 6 and 12 months to assess progress and identify future needs. Some people pair two Vigor Shots with a series of Firm Wave™ treatments based on preference and clinician advice. [4–5]
Downtime. Many people resume daily activities the same day. To reduce infection risk at the injection sites, clinicians often recommend avoiding sexual activity with a partner for about a week after the Vigor Shot procedure. Follow your clinician’s guidance regarding sexual activity and exercise. [4–5]
If you have urgent concerns after a procedure, seek immediate medical care or call emergency services.
A licensed clinician will personalize timing, comfort steps, and follow ups. Results vary by person and protocol.
Post-Procedure Care
At home: Expect localized tenderness or bruising for a few days. Use simple measures (for example, cold packs) unless told otherwise. Avoid new supplements/meds without clearance from a licensed clinician. [4–5]
Activity and sexual function: To lower the risk of infection at the injection sites, clinicians typically advise Vigor Shot recipients to avoid sexual activity with a partner for about one week. Ask your Vigor Shot provider about when to resume sexual activity; advice varies by case and comfort.
Urgent red flags—seek care right away [uncommon]: Seek urgent care if you experience rapidly worsening pain, spreading redness, fever, significant bleeding, difficulty urinating, or a prolonged erection lasting four hours or more. [4–5]
Follow‑ups: Typically at one to three months to review outcomes and next steps. [4–5]
Outcomes and Results
When changes might be noticed. In studies that reported improvements, some men noticed score changes within one to three months. Others showed no meaningful difference versus placebo. [1–5]
Durability. Reported follow ups are typically weeks to a few months. Long term durability is not well established. [1–2,4–5]
How success is measured. Licensed clinicians often use validated questionnaires such as the International Index of Erectile Function—Erectile Function domain and the Erection Hardness Score to track patient outcomes. Recording any other therapies helps avoid confusion about what is helping. [14,6]
Transparency note. If you want guaranteed or permanent results, PRP is not the right fit today. Evidence is evolving and outcomes vary. [1–2,6–7,13–14]
Success Stories
Patient stories can be encouraging, yet they are examples, not promises. The experiences and results shown or discussed may not occur for all patients. Simply put, individual results vary.
David Brackett | Hyper PRP™ Success Story
At 42, David Brackett felt like he was running on fumes — constant fatigue, brain fog, and a loss of drive that no amount of rest could fix. He discovered his symptoms were connected to low testosterone and poor cellular recovery. That’s when he began exploring Hyper PRP™ — a regenerative treatment that uses your own growth factors to help restore vitality, cellular function, and performance from within.
Who is a candidate?
and how sex therapy fits
Who the Vigor Shot is intended for:
after a licensed clinician reviews your history, labs, and goals
- Adults with erectile dysfunction (ED) who want a minimally invasive, investigational option as part of a comprehensive plan. [13–14]
- People open to screening and correcting testosterone deficiency first or in parallel, because low testosterone can blunt vascular and tissue responses to Hyper PRP. [15–16]
- Patients willing to combine approaches as needed—Calibrated TRT™ pellets when deficiency is confirmed (pellets are one of several guideline‑recognized TRT options), lifestyle steps, and established ED therapies such as prescription medications—so physiology and psychology are addressed together. [14–16]
- People open to sex therapy with a qualified clinician when psychosexual factors (for example, performance anxiety, avoidance, relationship or communication challenges) are part of the picture. Pairing sex therapy with the Vigor Shot may support confidence, adherence, and overall outcomes. [13–14]
- Those comfortable with careful expectation‑setting (results vary) and outcome tracking using validated questionnaires. [13–14]
Hyper PRP is usually postponed or may not be right for you if:
- You have an active infection (fever; red, warm, or draining skin).
- You have bleeding or clotting problems (for example, hemophilia, very low platelets, or other diagnosed clotting disorders).
- You have a tendency to form blood clots or had a recent clot and are not yet stable on treatment.
- You have severe anemia (very low red blood cells).
- You have a blood cancer (such as leukemia) and are not in a stable remission under your cancer doctor’s care.
- You are pregnant or breastfeeding (for elective hair/skin services like microneedling with PRP).
- Your doctor has told you to avoid injections or blood draws for now.
Not sure? Talk with a licensed clinician. If you have one of the conditions above, ask your primary-care clinician—and the specialist who manages it (for example, a hematologist, oncologist, or OB-GYN)—for guidance and clearance.
This list provides examples and is not exhaustive. Talk with a licensed provider to decide if Hyper PRP is appropriate for you. Results vary.
Correcting Testosterone Deficiency in Parallel
Why it matters
Before starting a Vigor Shot™ program, candidates with erectile dysfunction (ED) who are not receiving testosterone replacement therapy (TRT) should be screened for testosterone deficiency. Low testosterone can blunt sexual motivation, the physiology that drives erections, and the body’s ability to respond to regenerative care. As a result, any benefit from the Vigor Shot may be reduced or short-lived because the hormonal environment that supports libido, mood, blood flow mediated by nitric oxide (NO), and erectile tissue maintenance is underpowered. [15–16]
How Hyper PRP™ protocols address it
Our standards‑based Growth Factor Therapy™ (GFT) framework includes endocrine screening. If testing confirms testosterone deficiency, TRT options may be discussed. One option is Calibrated TRT™ pellets—a clinician‑directed form of replacement designed to maintain physiologic hormone levels for months at a time. Pellets are one of several guideline‑recognized TRT modalities.
Why pairing matters
Hormonal balance and penile tissue health are tightly linked. Testosterone supports:
- Nitric oxide production for stronger vascular responsiveness, which helps blood flow into erectile tissue.
- Smooth-muscle maintenance in the corpora cavernosa, important for rigidity and veno‑occlusion.
- Sexual motivation and confidence, which can reinforce the mind–body feedback loop that helps sustain erections.
Addressing testosterone deficiency in parallel with PRP helps ensure the biologic groundwork is sound—so the regenerative signals delivered by the Vigor Shot are not working against a hormonal headwind. [6,15]
Our clinical stance [screening and shared decisions]
Within the Hyper PRP standards‑based GFT framework, testosterone‑deficiency screening is a required step for adults being considered for the Vigor Shot who are not receiving TRT and do not have a recent, documented total testosterone blood test result. Screening helps identify hormone issues that could limit the response to—and effectiveness of—regenerative procedures such as Vigor Shot™ or Firm Wave™.
Using this framework is optional. Whether to follow it—and which tests or treatments to pursue—is at the discretion of you and your licensed clinician. The framework supports consistent, evidence-informed care. It does not replace clinical judgment or your preferences.
All testing and treatment choices are made jointly by you and your licensed clinician after reviewing benefits and risks, checking for contraindications, and deciding whether you are a good candidate.
If low testosterone is confirmed and hormone therapy is appropriate, options may be discussed. These options can include Calibrated TRT™ pellets. Pellets are one of several guideline-recognized ways to replace testosterone. Any therapy is prescribed and managed by the treating clinician. [15–18]
Transparency: PRP injections for ED and testosterone therapy follow different regulatory pathways. PRP use for ED is investigational; TRT follows established medical guidelines. Combining them is a clinical‑judgment decision grounded in physiology and patient preference.
The Vigor Shot™ + Sex Therapy
Why it matters
Erectile dysfunction often has both physical and psychological contributors—such as performance anxiety, avoidance, relationship or communication stress. These factors can reinforce one another: repeated difficulty can lower confidence, increase worry about “reliability,” and dampen arousal, creating a detrimental penis-brain feedback loop that is hard to break. Sex therapy addresses thoughts, behaviors, and partner communication in a structured way, and major guidelines support counseling as part of ED care. [13–14]
PRP for ED (the Vigor Shot) remains investigational, and results in human studies are mixed. Pairing PRP with sex therapy is a patient preference strategy grounded in the biopsychosocial model of ED and the guideline emphasis on counseling. You and your licensed clinician should set expectations, decide together, and measure your results over time. [1–5,13–14]
How Hyper PRP™ protocols address it
Our standards‑based Growth Factor Therapy™ (GFT) framework includes screening for psychosexual contributors. When these are present—or when the patient prefers to include counseling—the Hyper PRP provider should offer referral or co‑management with a licensed mental health or sex therapy clinician. Plans may coordinate therapy visits with PRP sessions, so you are working on mind and body in parallel. Participation is optional and based on shared decision making.
What sex therapy typically covers
Sex therapy is skills-based and collaborative. Depending on your needs, it may include:
- Reducing performance anxiety (for example, cognitive and breathing strategies; graded exposure to intimacy without pressure).
- Rebuilding approach behaviors and pleasure (for example, structured exercises that focus on sensation and connection rather than immediate intercourse).
- Improving communication and partnership, including navigating avoidance cycles, mismatched desire, or worry after a prior negative experience.
Your therapist may also coordinate with your medical team to review medication side effects, pain conditions, or other factors that affect intimacy.
Why pairing may help
Physiology + psychology: If erections feel unreliable, early physiologic support (when chosen) can offer tangible wins that support confidence and reduce anticipatory anxiety—helping you engage in therapy tasks.
Less sympathetic overactivation: Anxiety can increase “fight-or-flight” responses that work against erection. Therapy aims to reduce these responses while the patient pursues physiological improvements in erectile function.
Sustained behavior change: Counseling can help maintain healthy sexual routines and communication after any medical intervention.
These are plausible benefits, not guarantees. A clear plan, steady follow‑up, and validated measures help your licensed clinician learn what works for you.
Our clinical stance (counseling and shared decisions)
Within the Hyper PRP standards-based GFT framework, considering sex therapy is encouraged when psychosexual factors are present or when you prefer a whole person approach. Whether to include counseling—and how to sequence it with the Vigor Shot—is at the discretion of you and your licensed clinician(s), and may involve a licensed sex‑therapy professional. All choices should be made jointly after reviewing potential benefits and risks, checking for contraindications to any procedure or medication, and confirming you are a good candidate for the plan.
Transparency: PRP use for ED is investigational and not FDA‑approved; sex therapy is guideline‑supported for many men with ED. Combining them has not been proven to yield additive effects in controlled trials. Results vary. You and your Vigor Shot provider should discuss alternatives, agree on a plan, and track outcomes (for example, IIEF-EF, Erection Hardness Score, treatment satisfaction measures) to determine whether the approach is helping you.
Important Safety Information — Vigor Shot™ / Hyper PRP™ for Erectile Function Investigational
What this service is
Vigor Shot™ uses autologous platelet‑rich plasma (PRP) prepared from your own blood—within a standards‑based workflow—and injected into erectile tissue as part of a personalized plan. Use of PRP to restore sexual performance or erectile function is investigational. Results vary. [13–14]
Regulatory status (U.S.)
PRP preparation devices are FDA‑cleared to produce PRP at the point of care.
PRP injections for erectile dysfunction (ED) are not FDA‑approved. Major societies (SMSNA/EAU) classify penile PRP as experimental/investigational and advise limiting use to research settings or offering it with full transparency. [13–14]
Many device summaries state PRP “has not been evaluated for any clinical indications” and is not indicated for intravascular delivery. [19–21]
Who may be considered [after evaluation]
Adults with ED who want a minimally invasive, investigational option as part of a comprehensive plan that can include guideline‑supported therapies (for example, prescription tablets), lifestyle measures, and—in appropriate cases—sex therapy and assessment/treatment of testosterone deficiency. Final candidacy is decided by you and your licensed clinician.
Screening and focused baseline evaluation [what is typically assessed]
Before treatment, you and your clinician conduct a focused review to decide whether the Vigor Shot™ is appropriate for you. This is not a full general intake. The review covers erectile dysfunction history, cardiovascular risk, current medicines with attention to anticoagulants and antiplatelets, bleeding history, infection risk, and wellness factors such as sleep, exercise, alcohol use, and nicotine exposure. Endocrine factors such as testosterone deficiency are assessed. When deficiency is confirmed and hormone therapy is not contraindicated, testosterone replacement therapy, including pellets, may be discussed, as recognized in clinical guidelines. Psychosexual contributors may be identified and, when relevant, sex therapy can be offered alongside medical care [2]. You and your clinician set clear goals, align expectations, and agree to track progress with validated measures such as the International Index of Erectile Function Erectile Function domain (IIEF-EF) and the Erection Hardness Score.
Sexual function history: Depending on your comfort level, the evaluation may include a dedicated discussion of your sexual function. This covers current and past sexual performance, overall sexual health and wellness, and erectile capability such as hardness, durability, ability to start and maintain erections, and the presence of morning or nighttime erections. It also asks about satisfaction and distress, partner context, and any pain or curvature. Screening questions explore psychosexual contributors such as performance anxiety, avoidance, relationship or communication stress, prior negative experiences, mood symptoms, and substance use. When these factors are present, sex therapy can be discussed as a parallel option so that mind and body are addressed together.
How the procedure is performed [typical elements]
A small blood sample is drawn and processed to prepare Hyper PRP. The area is cleansed, topical and/or local anesthesia is used to numb the penis, and PRP is injected into the erectile chambers (corpora cavernosa) by a trained clinician. Visits typically last about one hour. Many people return to daily activities the same day, though your specific plan may differ.
Potential risks and side effects.
Most effects are temporary and related to the injection itself. Common experiences include injection site pain or pressure, bruising, swelling, temporary numbness or tingling, and minor bleeding. Less common or rare effects, whether reported or theoretical, include infection, hematoma, vasovagal episodes, allergic reaction to local anesthetic, scarring or fibrosis, vascular or nerve injury, and priapism which is a prolonged erection. Seek urgent care for the red flag symptoms listed below. Because medicines can affect safety and response, disclose all prescriptions and supplements, especially blood thinners, antiplatelets, medicines for erections, and alpha blockers. Only your prescribing clinician should adjust medications. [4–5]
Who should NOT receive this service [examples].
Certain conditions mean the procedure is not appropriate. Absolute contraindications include an active infection at the treatment site, critical thrombocytopenia or an uncontrolled bleeding disorder, severe anemia, known platelet function disorders, known hypersensitivity to components used for local anesthesia, or inability to provide informed consent. Other circumstances call for case by case judgment, such as anticoagulation that cannot be managed safely, poorly controlled diabetes, unstable cardiovascular disease, active genital dermatoses, or active malignancy under treatment. This is not an exhaustive list, so discuss your history with a licensed clinician. [4–5]
Evidence expectations (what current studies show).
Small, short term human studies show mixed results. Some report modest improvements in erectile function scores, while others show no difference compared with placebo. Long term durability is not established, and the optimal PRP formulation and treatment schedule are still being studied. Results vary [1–5,12].
After care and urgent concerns.
Follow your clinician’s instructions about activity and sexual activity after the procedure. Temporary soreness or bruising is common. Seek immediate medical care or call emergency services for rapidly worsening pain, spreading redness or warmth, fever, significant bleeding, difficulty urinating, or an erection lasting four hours or more [4–5].
Informed choices and alternatives.
Decisions are made jointly by you and your licensed clinician after reviewing benefits, risks, and alternatives. Alternatives may include PDE5 inhibitors, Firm Wave™ Therapy, intracavernosal pharmacotherapy, sex therapy, and other options. Your Vigor Shot provider uses shared decision making and tracks outcomes with validated measures to understand how the plan is working for you.
Expectations and Variability
Benefit is not guaranteed; protocols and patient biology affect outcomes. You and your licensed clinician should set goals, track validated measures, and adjust the plan.
How to Report Issues
Report suspected device/product problems or serious adverse events to the FDA MedWatch program.
You may also file a complaint about clinical care with your State’s Medical Board.
See:Expanded Candidate InformationFull Important Safety Information
Research about using PRP to treat ED
Supporting Scientific Evidence
What early studies suggest about using PRP for ED
Microvascular support and nitric oxide signaling.Animal studies report higher endothelial markers and more eNOS expression after intracavernosal PRP, along with better erectile measurements compared with saline in those models.
Smooth muscle preservation and less fibrosis.Diabetic and nerve injury models show a healthier smooth muscle to collagen balance, which may help the natural venous seal and overall rigidity.
Nerve support. After experimental injury of the cavernous nerves, PRP has been linked with improved nerve staining and erectile responses in animals.
Current takeaway.These findings are encouraging but they are preclinical, and human tissue level confirmation is still limited. [11–12]
What human studies show right now
Function signals.Most studies in men track validated scores such as IIEF-EF or the Erection Hardness Score. Reviews report mixed results. Some men see short term functional improvement while others do not.
Room for better data.Protocols vary across studies, which makes comparisons difficult. Professional societies currently view penile PRP as investigational, and larger standardized trials are needed. [1–5]
Frequently Asked Questions
Alternatives and Related Services
- Calibrated TRT™
- Firm Wave™
- Sex Therapy
Citations and References
Grouped by subject
Indication efficacy — meta-analyses and systematic reviews
1. Panunzio A, Labate C, Zacheo F, et al. Platelet-rich plasma intracavernosal injections for primary organic erectile dysfunction: systematic review and meta-analysis. Int J Impot Res. 2024;36(6):562-571. doi:10.1038/s41443-023-00798-y. PMID:37993601.
2. Mao Q, Ding X, et al. Efficacy of platelet-rich plasma in the treatment of erectile dysfunction: meta-analysis. Hum Vaccin Immunother. 2024. doi:10.1080/13685538.2024.2358944.
3. Asmundo MG, Barra F, et al. PRP therapy in erectile dysfunction and Peyronie’s disease: review. Transl Androl Urol. 2024. Online ahead of print.
Randomized and controlled clinical trials for erectile dysfunction
4. Masterson TA, Molina M, Ledesma B, et al. Platelet-rich plasma for the treatment of erectile dysfunction: a prospective, randomized, double-blind, placebo-controlled clinical trial. J Urol. 2023;210(1):154-161. doi:10.1097/JU.0000000000003481. PMID:37120727.
5. Poulios E, Mykoniatis I, Pyrgidis N, et al. Platelet-rich plasma improves erectile function: a double-blind, randomized, placebo-controlled clinical trial. J Sex Med. 2021;18(5):926-935. doi:10.1016/j.jsxm.2021.03.008. PMID:33906807.
PRP biology, dosing, and delivery methods (plus erectile physiology and preclinical context)
6. Yafi FA, Jenkins L, Albersen M, et al. Erectile dysfunction. Nat Rev Dis Primers. 2016;2:16003. doi:10.1038/nrdp.2016.3.
7. Anastasiadis E, Ahmed R, Khoja AK, Yap T. Erectile dysfunction: Is platelet-rich plasma the new frontier? Front Reprod Health. 2022;4:944765. doi:10.3389/frph.2022.944765.
8. Magalon J, Chateau AL, Bertrand B, et al. DEPA classification: a proposal for standardising platelet-rich plasma use. BMJ Open Sport Exerc Med. 2016;2:e000060. doi:10.1136/bmjsem-2015-000060.
9. Tey RV, Rahim MS, Kamarul T, et al. Variability in platelet-rich plasma preparations used in clinical studies. Orthop J Sports Med. 2022;10(10):23259671221120817. PMID:36186118.
10. Khodamoradi K, Dullea A, Golan R, et al. Platelet-rich plasma growth factor concentration varies in men with erectile dysfunction. J Sex Med. 2022;19(9):1488-1493. doi:10.1016/j.jsxm.2022.06.003. PMID:35817715.
11. Song G, Zhang C, Wang Z, et al. Cavernous-nerve injury-induced erectile dysfunction: mechanisms and experimental therapies. Front Physiol. 2022;13:1029360.
12. Tai HC, Wu CC, Wu YN, et al. Intracavernosal platelet-rich plasma in diabetic and nerve-injury erectile-dysfunction models: endothelial, antifibrotic, and neurotrophic signals with improved erectile pressures. FASEB J. 2023.
Guidelines, consensus statements, and practice recommendations
13. Liu JL, Chu KY, Gabrielson AT, et al. Restorative therapies for erectile dysfunction: Position Statement from the Sexual Medicine Society of North America. Sex Med. 2021;9(3):100343. doi:10.1016/j.esxm.2021.100343. PMID:34000480.
14. Burnett AL, Nehra A, Breau RH, et al. Erectile Dysfunction: AUA Guideline. J Urol. 2018;200(3):633-641. doi:10.1016/j.juro.2018.05.004. PMID:29746858.
Adjuncts and combination therapies relevant to erectile dysfunction
15. Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744. doi:10.1210/jc.2018-00229. PMID:29562364.
16. Mulhall JP, Trost LW, Brannigan RE, et al. Evaluation and management of testosterone deficiency: AUA Guideline. J Urol. 2018;200(2):423-432. doi:10.1016/j.juro.2018.03.115. PMID:29601923.
17. Snyder PJ, Bhasin S, Cunningham GR, et al. Effects of testosterone treatment in older men. N Engl J Med. 2016;374(7):611-624. doi:10.1056/NEJMoa1506119. PMID:26886521.
18. Spitzer M, Basaria S, Travison TG, et al. Effect of testosterone replacement on response to sildenafil in men with erectile dysfunction: a randomized trial. Ann Intern Med. 2012;157(10):681-691. doi:10.7326/0003-4819-157-10-201211200-00004. PMID:23165659.
Regulatory status, labeling limits, and safety reporting (United States)
19. U.S. Food and Drug Administration. 510(k) Summary — OrthoAscent FG001 PRP Device (BK241083). 2024.
20. Agency for Healthcare Research and Quality / NCBI Evidence Summary. Platelet-rich plasma for wound care in the Medicare population. 2020. Notes FDA clearance of devices to prepare PRP.
21. U.S. FDA MedWatch. Reporting serious problems to FDA. Accessed 2025.
Important reminder. This information is educational and does not replace medical advice. Talk with a qualified clinician to see whether the Vigor Shot is appropriate for you, to review alternatives, and to understand potential benefits and risks.
Important Notice
Results are not guaranteed; individual results vary. Some uses—including ED—are investigational. Hyper PRP is prepared using FDA-cleared devices for PRP preparation; PRP injections for specific conditions are not FDA-approved and are not indicated for intravascular delivery. This site is informational and does not establish a doctor-patient relationship. Do not submit sensitive health information through web forms. If this is an emergency, call 911.